Vitamin D3-elicited CD14+ human skin dendritic cells promote thymic stromal lymphopoietin-independent type 2 T-helper responses.

Fiche publication

Date publication

juillet 2021

Journal

Allergy

Auteurs

Membres identifiés du Cancéropôle Est :
Dr MUELLER Christopher , Dr FLACHER Vincent

Tous les auteurs :
Brulefert A, Hoste A, Muller Q, Fauny JD, Mueller CG, Flacher V

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/33368331

Résumé

Immune modulation by vitamin D3 through dendritic cells (DCs) remains controversial. Human DCs exposed in vitro counteract type-1 T-helper (Th1) differentiation and induce regulatory T cells. However, cutaneous application on mice promotes Th2-driven inflammation resembling atopic dermatitis and relying on thymic stromal lymphopoietin (TSLP) from keratinocytes and T-cell orientation by TSLP-stimulated skin DCs. We studied the effects of vitamin D3 in human skin, focusing on TSLP production and the role of skin DCs in T-cell differentiation.