Impact of Inhaled Corticosteroids on the Modulation of Respiratory Defensive Reflexes During Artificial Limb Exercise in Ovalbumin-Sensitized Rabbits.

Fiche publication

Date publication

janvier 2021

Journal

Frontiers in physiology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr CHENUEL Bruno , Pr POUSSEL Mathias

Tous les auteurs :
Basin S, Valentin S, Demoulin-Alexikova S, Demoulin B, Foucaud L, Gérard D, Pouget C, Allado E, Chenuel B, Poussel M

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/35145425

Résumé

Cough is a major lower airway defense mechanism that can be triggered by exercise in asthma patients. Studies on cough reflex in experimental animal models revealed a decrease of cough reflex sensitivity during exercise in healthy animals, but a lack of desensitization in ovalbumin-sensitized rabbits. The aim of our study is to evaluate the impact of inhaled corticosteroids on cough reflex during artificial limb exercise in an animal model of eosinophilic airway inflammation.