Complement Activation and Thrombotic Microangiopathy Associated With Monoclonal Gammopathy: A National French Case Series.

Fiche publication

Date publication

février 2022

Journal

American journal of kidney diseases : the official journal of the National Kidney Foundation

Auteurs

Membres identifiés du Cancéropôle Est :
Pr DUCLOUX Didier

Tous les auteurs :
Martins M, Bridoux F, Goujon JM, Meuleman MS, Ribes D, Rondeau E, Guerry MJ, Delmas Y, Levy B, Ducloux D, Kandel-Aznar C, Le Fur A, Garrouste C, Provot F, Gibier JB, Thervet E, Bruneval P, Rabant M, Karras A, Dragon Durey MA, Bacchi VF, Chauvet S

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/35217094

Résumé

Hemolytic uremic syndrome (HUS), a thrombotic microangiopathy (TMA) with kidney involvement, is a rare condition in patients with monoclonal gammopathy. In the absence of known causes of thrombotic microangiopathy, the role of complement activation in endothelial injury in patients with monoclonal gammopathy remains unknown and was the focus of this investigation.