Fiche publication
Date publication
mars 2022
Journal
iScience
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GOETZ Jacky
,
Dr OSMANI Naël
Tous les auteurs :
Peralta M, Osmani N, Goetz JG
Lien Pubmed
Résumé
During cancer progression, metastatic dissemination accounts for ∼90% of death in patients. Metastasis occurs upon dissemination of circulating tumor cells (CTC) through body fluids, in particular the bloodstream, and several key steps remain elusive. Although the majority of CTCs travel as single cells, they can form clusters either with themselves (homoclusters) or with other circulating cells (heteroclusters) and thereby increase their metastatic potential. In addition, cancer cell mechanics and mechanical cues from the microenvironment are important factors during metastatic progression. Recent progress in intravital imaging technologies, biophysical methods, and microfluidic-based isolation of CTCs allow now to probe mechanics at single cell resolution while shedding light on key steps of the hematogenous metastatic cascade. In this review, we discuss the importance of CTC mechanics and their correlation with metastatic success and how such development could lead to the identification of therapeutically relevant targets.
Mots clés
Biological sciences, Biological sciences research methodologies, Cancer, Mechanobiology
Référence
iScience. 2022 Mar 18;25(3):103969
