Fiche publication


Date publication

avril 2022

Journal

Journal of cachexia, sarcopenia and muscle

Auteurs

Membres identifiés du Cancéropôle Est :
Pr PIVOT Xavier , Dr SCHOTT Roland , Dr BENDER Laura , Pr FAVRET Fabrice , Pr GENY Bernard , Dr HUCTEAU Elyse , Dr MALLARD Joris


Tous les auteurs :
Mallard J, Hucteau E, Charles AL, Bender L, Baeza C, Pélissie M, Trensz P, Pflumio C, Kalish-Weindling M, Gény B, Schott R, Favret F, Pivot X, Hureau TJ, Pagano AF

Résumé

Chemotherapy is extensively used to treat breast cancer and is associated with skeletal muscle deconditioning, which is known to reduce patients' quality of life, treatment efficiency, and overall survival. To date, skeletal muscle mitochondrial alterations represent a major aspect explored in breast cancer patients; nevertheless, the cellular mechanisms remain relatively unknown. This study was dedicated to investigating overall skeletal muscle mitochondrial homeostasis in early breast cancer patients undergoing chemotherapy, including mitochondrial quantity, function, and dynamics.

Mots clés

Apoptosis, H2O2, Mitochondrial biogenesis, Mitochondrial dynamics, Mitophagy, Skeletal muscle deconditioning

Référence

J Cachexia Sarcopenia Muscle. 2022 Apr 4;: