Fiche publication
Date publication
avril 2022
Journal
Cells
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BONNIAUD Philippe
,
Dr BELTRAMO Guillaume
Tous les auteurs :
Burgy O, Loriod S, Beltramo G, Bonniaud P
Lien Pubmed
Résumé
Lipids are major actors and regulators of physiological processes within the lung. Initial research has described their critical role in tissue homeostasis and in orchestrating cellular communication to allow respiration. Over the past decades, a growing body of research has also emphasized how lipids and their metabolism may be altered, contributing to the development and progression of chronic lung diseases such as pulmonary fibrosis. In this review, we first describe the current working model of the mechanisms of lung fibrogenesis before introducing lipids and their cellular metabolism. We then summarize the evidence of altered lipid homeostasis during pulmonary fibrosis, focusing on their extracellular forms. Finally, we highlight how lipid targeting may open avenues to develop therapeutic options for patients with lung fibrosis.
Mots clés
extracellular lipids, idiopathic pulmonary fibrosis, lipid metabolism
Référence
Cells. 2022 Apr 3;11(7):
