Methylene Blue Reduces Fluid Loading and Norepinephrine Requirements for Post-Resuscitation Syndrome in a Pig Model of Refractory Cardiac Arrest Resuscitated with Veno-Arterial ECMO.

Date publication

avril 2022

Journal

Journal of clinical medicine

Auteurs

Membres identifiés du Cancéropôle Est :
Pr ALBUISSON Eliane

Tous les auteurs :
Pequignot B, Lescroart M, Orlowski S, Reynette N, Martini B, Albuisson E, Pina H, Tran N, Grandmougin D, Levy B

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/35566640

Résumé

Refractory cardiac arrest management relies on extracorporeal cardiopulmonary resuscitation (ECPR), requiring the use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO). Circulatory flow recovery can be associated with an ischemia-reperfusion injury, leading to vasoplegia and vasopressor requirement. The aim of this work was to evaluate the impact on hemodynamics of a methylene blue bolus infusion in a porcine model of ischemic refractory cardiac arrest.

Mots clés

advanced cardiac life support, cardiopulmonary resuscitation, extracorporeal membrane oxygenation, inflammatory response, methylene blue, microcirculation, out-of-hospital cardiac arrest, vasopressor

Référence

J Clin Med. 2022 04 29;11(9):