How molecular modelling can better broaden the understanding of glycosylations.

Date publication

juin 2022

Journal

Current opinion in structural biology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr DAUCHEZ Manuel , Pr BAUD Stéphanie

Tous les auteurs :
Rao RM, Dauchez M, Baud S

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/35679802

Résumé

Glycosylations are among the most ubiquitous post-translational modifications (PTMs) in proteins, and the effects of their perturbations are seen in various diseases such as cancers, diabetes and arthritis to name a few. Yet they remain one of the most enigmatic aspects of protein structure and function. On the other hand, molecular modelling techniques have been rapidly bridging this knowledge gap since the last decade. In this review, we discuss how these techniques have proven to be indispensable for a better understanding of the role of glycosylations in glycoprotein structure and function.

Référence

Curr Opin Struct Biol. 2022 06 6;75:102393