Fiche publication
Date publication
mai 2022
Journal
Cancers
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VEGRAN Frédérique
,
Dr BRUCHARD Mélanie
Tous les auteurs :
Geindreau M, Bruchard M, Vegran F
Lien Pubmed
Résumé
During carcinogenesis, tumors set various mechanisms to help support their development. Angiogenesis is a crucial process for cancer development as it drives the creation of blood vessels within the tumor. These newly formed blood vessels insure the supply of oxygen and nutrients to the tumor, helping its growth. The main factors that regulate angiogenesis are the five members of the vascular endothelial growth factor (VEGF) family. Angiogenesis is a hallmark of cancer and has been the target of new therapies this past few years. However, angiogenesis is a complex phenomenon with many redundancy pathways that ensure its maintenance. In this review, we will first describe the consecutive steps forming angiogenesis, as well as its classical regulators. We will then discuss how the cytokines and chemokines present in the tumor microenvironment can induce or block angiogenesis. Finally, we will focus on the therapeutic arsenal targeting angiogenesis in cancer and the challenges they have to overcome.
Mots clés
angiogenesis, cancer, chemokines, cytokines, therapy
Référence
Cancers (Basel). 2022 05 16;14(10):
