Unravelling the etiology of sporadic late-onset cerebellar ataxia in a cohort of 205 patients: a prospective study.

Date publication

juillet 2022

Journal

Journal of neurology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr NAMER Izzie-Jacques , Dr BUND Caroline

Tous les auteurs :
Bogdan T, Wirth T, Iosif A, Schalk A, Montaut S, Bonnard C, Carre G, Lagha-Boukbiza O, Reschwein C, Albugues E, Demuth S, Landsberger H, Einsiedler M, Parratte T, Nguyen A, Lamy F, Durand H, Fahrer P, Voulleminot P, Bigaut K, Chanson JB, Nicolas G, Chelly J, Cazeneuve C, Koenig M, Bund C, Namer IJ, Kremer S, Calmels N, Tranchant C, Anheim M

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/35869996

Résumé

Despite recent progress in the field of genetics, sporadic late-onset (> 40 years) cerebellar ataxia (SLOCA) etiology remains frequently elusive, while the optimal diagnostic workup still needs to be determined. We aimed to comprehensively describe the causes of SLOCA and to discuss the relevance of the investigations.

Mots clés

Brain MRI, Genetics, I123-ioflupane SPECT, Late-onset cerebellar ataxia, Multiple system atrophy

Référence

J Neurol. 2022 07 23;: