Tear analysis as a tool to detect oligoclonal bands in radiologically isolated syndrome.

Date publication

avril 2015

Journal

Revue neurologique

Auteurs

Membres identifiés du Cancéropôle Est :
Pr DE SEZE Jérôme

Tous les auteurs :
Lebrun C, Forzy G, Collongues N, Cohen M, de Seze J, Hautecoeur P,

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25613196

Résumé

Although radiologically isolated syndrome (RIS) is a newly defined entity, incidental findings of T2 hypersignals on brain MRI can lead to misdiagnosis or useless investigations. The detection of oligoclonal bands (OCBs) in cerebrospinal fluid (CSF) is a major indicator that helps in diagnosis of subclinical inflammatory disease of the central nervous system, but lumbar puncture still remains an invasive option.

Mots clés

Adult, Brain, pathology, Female, Humans, Isoelectric Focusing, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, cerebrospinal fluid, Oligoclonal Bands, analysis, Prospective Studies, Spinal Puncture, Tears, chemistry, Young Adult

Référence

Rev. Neurol. (Paris). 2015 Apr;171(4):390-3