The Lauren classification highlights the role of epithelial-to-mesenchymal transition in gastric carcinogenesis: an immunohistochemistry study of the STAT3 and adhesion molecules expression.

Date publication

mars 2015

Journal

Journal of gastrointestinal and liver diseases : JGLD

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BIBEAU Frédéric

Tous les auteurs :
Susman S, Barnoud R, Bibeau F, Borrini F, Pocard M, Tomuleasa C, Sabourin JC

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25822437

Résumé

Despite some recent advances, gastric cancer remains an important cause of death at world level. This indicates an absence of therapeutic options, stemming from the limited understanding of the molecular mechanisms involved in carcinogenesis. Nearly fifty years ago Lauren classified gastric cancers, according to the morphological aspect, as intestinal or diffuse. The phenotype of the cells indicates the presence of different molecular mechanisms, which can be approached in the light of recent data and identified with the help of current techniques. The best described are the germline/somatic mutations or the hypermethylations of the E-cadherin 1 CDH1 gene promotor.

Mots clés

Adenocarcinoma, chemistry, Adult, Aged, Aged, 80 and over, Antigens, CD, Biomarkers, Tumor, analysis, Cadherins, analysis, Cell Adhesion Molecules, analysis, Epithelial-Mesenchymal Transition, Europe, Female, Humans, Immunohistochemistry, Male, Middle Aged, Phosphorylation, Prognosis, STAT3 Transcription Factor, analysis, Stomach Neoplasms, chemistry, Tissue Array Analysis, alpha Catenin, analysis, beta Catenin, analysis

Référence

J Gastrointestin Liver Dis. 2015 03;24(1):77-83