Towards the elaboration of new gold-based optical theranostics.

Date publication

mars 2015

Journal

Dalton transactions (Cambridge, England : 2003)

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BETTAIEB Ali , Dr DUBREZ Laurence , Pr PAUL Catherine , Pr DENAT Franck , Dr GONCALVES Victor , Dr DECREAU Richard

Tous les auteurs :
Doulain PE, Decréau R, Racoeur C, Goncalves V, Dubrez L, Bettaieb A, Le Gendre P, Denat F, Paul C, Goze C, Bodio E

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25492395

Résumé

Four new red BODIPY-gold(I) theranostic compounds were synthesized. Some of them were vectorized by tethering a biovector (glucose or bombesin derivatives) to the metallic center. Their photophysical properties were studied. Additionally, their cytotoxicity was examined on different cancer cell lines and on a normal cell line, they were tracked in vitro by fluorescence detection, and their uptake was evaluated by ICP-MS measurements.

Mots clés

Biological Transport, Bombesin, metabolism, Boron Compounds, chemistry, Cell Line, Tumor, Gold, chemistry, Humans, Microscopy, Fluorescence, Optical Imaging, methods, Organometallic Compounds, chemistry

Référence

Dalton Trans. 2015 Mar;44(11):4874-83