Fiche publication
Date publication
février 2015
Journal
Dalton transactions (Cambridge, England : 2003)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DECREAU Richard
,
Pr PERRIER-CORNET Jean-Marie
Tous les auteurs :
Bernhard Y, Winckler P, Perrier-Cornet JM, Decréau RA
Lien Pubmed
Résumé
Subphthalocyanine (SubPc), a putative fluorophore for optical imaging (OI), was conjugated to chelating ligands (DOTA, DTPA) affording water-soluble conjugates complexed with (non-radioactive) metals relevant to the following medical imaging techniques/therapies: MRI (Gd), PET (Cu, Ga), SPECT (In, Ga, Lu), RIT (Cu, Lu, Y), and NCT (Gd). Magneto-optical properties of ditopic gadolinium species (and optical properties of other metal containing species) were examined (brightness (ε × ΦF) and relaxivity R1) and fluorescence confocal/biphoton microscopy studies were conducted.
Mots clés
Cell Line, Tumor, Cell Survival, drug effects, Humans, Indoles, chemistry, Magnetic Resonance Spectroscopy, methods, Melanoma, Experimental, chemistry, Metals, chemistry, Solubility, Water, chemistry
Référence
Dalton Trans. 2015 Feb 21;44(7):3200-8
