Flexible modeling of longitudinal health-related quality of life data accounting for informative dropout in a cancer clinical trial.

Fiche publication

Date publication

septembre 2022

Journal

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

Auteurs

Membres identifiés du Cancéropôle Est :
Pr CONROY Thierry

Tous les auteurs :
Winter A, Cuer B, Conroy T, Juzyna B, Gourgou S, Mollevi C, Touraine C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/36115002

Résumé

A joint modeling approach is recommended for analysis of longitudinal health-related quality of life (HRQoL) data in the presence of potentially informative dropouts. However, the linear mixed model modeling the longitudinal HRQoL outcome in a joint model often assumes a linear trajectory over time, an oversimplification that can lead to incorrect results. Our aim was to demonstrate that a more flexible model gives more reliable and complete results without complicating their interpretation.