Fiche publication
Date publication
février 2015
Journal
Bone marrow transplantation
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MARTIN Thierry
Tous les auteurs :
Snarski E, Snowden JA, Oliveira MC, Simoes B, Badoglio M, Carlson K, Burman J, Moore J, Rovira M, Clark RE, Saiz A, Hadj-Khelifa S, Tan J, Crescimanno A, Musso M, Martin T, Farge D
Lien Pubmed
Résumé
Autologous haematopoietic SCT (AHSCT) is increasingly used to control severe and refractory autoimmune diseases (AD). Many patients are women of reproductive age with a potential desire for children. We present a multicentre retrospective analysis of pregnancy and childbirth in patients who underwent AHSCT for AD. The databases of the European Blood and Marrow Transplantation and University of Sao Paulo, Ribeirão Preto, Brazil were searched for female patients aged 18-50 years who had received AHSCT for AD between 1994-2011. In 324 adult female patients, 22 pregnancies were reported in 15 patients between 1997-2011. Indications for AHSCT included multiple sclerosis (n=7), systemic sclerosis (n=5), rheumatoid arthritis (n=1), juvenile idiopathic arthritis (n=1) and Takayasu disease (n=1). Of the 22 reported pregnancies, 20 followed natural conception. 15 pregnancies (68%) resulted in healthy life births, whereas 7 (32%) failed. Exacerbations of AD occurred in two patients during second pregnancies. No maternal mortality was associated with pregnancy or postpartum. There were no reports of congenital, developmental or any other disease in the children. This retrospective analysis confirms the possibility of pregnancy and childbirth following AHSCT for severe AD. The outcome of pregnancy is generally good and most led to the birth of a healthy child.
Mots clés
Adolescent, Adult, Autografts, Databases, Factual, Female, Hematopoietic Stem Cell Transplantation, Humans, Live Birth, Middle Aged, Pregnancy, Pregnancy Complications, therapy, Retrospective Studies
Référence
Bone Marrow Transplant.. 2015 Feb;50(2):216-20
