The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH neuronal development: Evidence from patients with idiopathic hypogonadotropic hypogonadism, zebrafish, and in vitro GAP activity assay.

Date publication

septembre 2022

Journal

Genetics in medicine : official journal of the American College of Medical Genetics

Auteurs

Membres identifiés du Cancéropôle Est :
Dr NAMBOT Sophie

Tous les auteurs :
Lippincott MF, Xu W, Smith AA, Miao X, Lafont A, Shennib O, Farley GJ, Sabbagh R, Delaney A, Stamou M, Plummer L, Salnikov K, Georgopoulos NA, Mericq V, Quinton R, Mau-Them FT, Nambot S, Hamad A, Brittain H, Tooze RS, Calpena E, Wilkie AOM, Willems M, Crowley WF, Balasubramanian R, Lamarche-Vane N, Davis EE, Seminara SB

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/36178483

Résumé

The study aimed to identify novel genes for idiopathic hypogonadotropic hypogonadism (IHH).

Mots clés

Developmental disorder, Idiopathic hypogonadotropic hypogonadism, Intellectual disability, Puberty, Rho GTPase–activating protein

Référence

Genet Med. 2022 09 29;: