Fiche publication
Date publication
octobre 2022
Journal
BMC biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr CIANFERANI Sarah
,
Mr ESSABRI Karim
,
Dr HAMICHE Ali
,
Dr MORAS Dino
,
Dr BILLAS Isabelle
Tous les auteurs :
Beinsteiner B, Markov GV, Bourguet M, McEwen AG, Erb S, Patel AKM, El Khaloufi El Khaddar FZ, Lecroisey C, Holzer G, Essabri K, Hazemann I, Hamiche A, Cianférani S, Moras D, Laudet V, Billas IML
Lien Pubmed
Résumé
Nuclear receptors are transcription factors of central importance in human biology and associated diseases. Much of the knowledge related to their major functions, such as ligand and DNA binding or dimerization, derives from functional studies undertaken in classical model animals. It has become evident, however, that a deeper understanding of these molecular functions requires uncovering how these characteristics originated and diversified during evolution, by looking at more species. In particular, the comprehension of how dimerization evolved from ancestral homodimers to a more sophisticated state of heterodimers has been missing, due to a too narrow phylogenetic sampling. Here, we experimentally and phylogenetically define the evolutionary trajectory of nuclear receptor dimerization by analyzing a novel NR7 subgroup, present in various metazoan groups, including cnidarians, annelids, mollusks, sea urchins, and amphioxus, but lost in vertebrates, arthropods, and nematodes.
Mots clés
Amphioxus, NR7; Crystal structure; Native mass spectrometry, Non-model animals, Nuclear receptor dimerization, Nuclear receptor phylogeny
Référence
BMC Biol. 2022 10 5;20(1):217
