Apparent Km of mitochondria for oxygen computed from Vmax measured in permeabilized muscle fibers is lower in water enriched in oxygen by electrolysis than injection.

Date publication

janvier 2015

Journal

Drug design, development and therapy

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GENY Bernard

Tous les auteurs :
Zoll J, Bouitbir J, Sirvent P, Klein A, Charton A, Jimenez L, Péronnet FR, Geny B, Richard R

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/26203225

Résumé

It has been suggested that oxygen (O2) diffusion could be favored in water enriched in O2 by a new electrolytic process because of O2 trapping in water superstructures (clathrates), which could reduce the local pressure/content relationships for O2 and facilitate O2 diffusion along PO2 gradients.

Mots clés

Km O2, TMPD–ascorbate, glutamate–malate, mitochondrial respiration, saponin-skinned fibers

Référence

Drug Des Devel Ther. 2015 ;9:3589-97