Dectin-1 Polymorphism: A Genetic Disease Specifier in Autism Spectrum Disorders?

Date publication

janvier 2015

Journal

PloS one

Auteurs

Membres identifiés du Cancéropôle Est :
Pr FEUGEAS Jean-Paul

Tous les auteurs :
Bennabi M, Delorme R, Oliveira J, Fortier C, Lajnef M, Boukouaci W, Feugeas JP, Marzais F, Gaman A, Charron D, Ghaleh B, Krishnamoorthy R, Leboyer M, Tamouza R

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/26352598

Résumé

In autism spectrum disorders (ASD), complex gene-environment interactions contribute to disease onset and progress. Given that gastro-intestinal dysfunctions are common in ASD, we postulated involvement of microbial dysbiosis in ASD and investigated, under a case-control design, the influence of DNA polymorphisms in the CLEC7A gene that encodes a pivotal fungal sensor, Dectin-1.

Mots clés

Adolescent, Adult, Alleles, Autism Spectrum Disorder, complications, Child, Child, Preschool, Dysbiosis, complications, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Immunity, Innate, genetics, Lectins, C-Type, genetics, Male, Middle Aged, Polymorphism, Single Nucleotide

Référence

PLoS ONE. 2015 ;10(9):e0137339