Fiche publication
Date publication
janvier 2015
Journal
Nanomedicine (London, England)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BEGIN-COLIN Sylvie
,
Dr FELDER-FLESCH Delphine
Tous les auteurs :
Parat A, Bordeianu C, Dib H, Garofalo A, Walter A, Bégin-Colin S, Felder-Flesch D
Lien Pubmed
Résumé
Nanomedicine can take advantage of the recent developments in nanobiotechnology research areas for the creation of platforms with superior drug carrier capabilities, selective responsiveness to the environment, unique contrast enhancement profiles and improved accumulation at the disease site. Colloidal inorganic nanoparticles (NPs) have been attracting considerable interest in biomedicine, from drug and gene delivery to imaging, sensing and diagnostics. It is essential to modify the NPs surface to have enhanced biocompatibility and reach multifunctional systems for the in vitro and in vivo applications, especially in delivering drugs locally and recognizing overexpressed biomolecules. This paper describes the rational design for dendrimer-nanoparticle conjugates elaboration and reviews their state-of-the-art uses as efficient nanomedicine tools.
Mots clés
Animals, Cell Line, Tumor, Contrast Media, Dendrimers, chemistry, Diagnostic Imaging, methods, Drug Carriers, Ferric Compounds, chemistry, Gold, chemistry, Humans, Metal Nanoparticles, chemistry, Molecular Imaging, Nanomedicine, methods, Nanoparticles, chemistry, Polymerase Chain Reaction, Quantum Dots
Référence
Nanomedicine (Lond). 2015 ;10(6):977-92
