Fiche publication
Date publication
janvier 2015
Journal
Clinical interventions in aging
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HUMBERT Philippe
,
Dr JEUDY Adeline
,
Mr LIHOREAU Thomas
Tous les auteurs :
Humbert P, Fanian F, Lihoreau T, Jeudy A, Elkhyat A, Robin S, Courderot-Masuyer C, Tauzin H, Lafforgue C, Haftek M
Lien Pubmed
Résumé
Loss of mechanical tension appears to be the major factor underlying decreased collagen synthesis in aged skin. Numerous in vitro studies have shown the impact of mechanical forces on fibroblasts through mechanotransduction, which consists of the conversion of mechanical signals to biochemical responses. Such responses are characterized by the modulation of gene expression coding not only for extracellular matrix components (collagens, elastin, etc.) but also for degradation enzymes (matrix metalloproteinases [MMPs]) and their inhibitors (tissue inhibitors of metalloproteinases [TIMPs]). A new device providing a mechanical stimulation of the cutaneous and subcutaneous tissue has been used in a simple, blinded, controlled, and randomized study.
Mots clés
Adult, Collagen Type I, biosynthesis, Cosmetic Techniques, adverse effects, Double-Blind Method, Elastin, biosynthesis, Extracellular Matrix, metabolism, Face, Female, Fibroblasts, metabolism, Humans, Hyaluronic Acid, biosynthesis, Male, Matrix Metalloproteinase 9, Middle Aged, Skin Aging
Référence
Clin Interv Aging. 2015 ;10:387-403
