Fiche publication
Date publication
janvier 2015
Journal
Frontiers in cellular and infection microbiology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GANGLOFF Sophie
,
Dr VELARD Frédéric
Tous les auteurs :
Josse J, Velard F, Gangloff SC
Lien Pubmed
Résumé
Bone cells, namely osteoblasts and osteoclasts work in concert and are responsible for bone extracellular matrix formation and resorption. This homeostasis is, in part, altered during infections by Staphylococcus aureus through the induction of various responses from the osteoblasts. This includes the over-production of chemokines, cytokines and growth factors, thus suggesting a role for these cells in both innate and adaptive immunity. S. aureus decreases the activity and viability of osteoblasts, by induction of apoptosis-dependent and independent mechanisms. The tight relationship between osteoclasts and osteoblasts is also modulated by S. aureus infection. The present review provides a survey of the relevant literature discussing the important aspects of S. aureus and osteoblast interaction as well as the ability for antimicrobial peptides to kill intra-osteoblastic S. aureus, hence emphasizing the necessity for new anti-infectious therapeutics.
Mots clés
Animals, Antimicrobial Cationic Peptides, metabolism, Apoptosis, Cell Survival, Host-Pathogen Interactions, Humans, Immunity, Innate, Microbial Viability, drug effects, Osteoblasts, immunology, Osteoclasts, microbiology, Osteomyelitis, microbiology, Staphylococcal Infections, microbiology, Staphylococcus aureus, drug effects
Référence
Front Cell Infect Microbiol. 2015 ;5:85
