Unusual association of myasthenia gravis and ulcerative colitis in a 14-year-old boy.

Date publication

janvier 2015

Journal

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

Auteurs

Membres identifiés du Cancéropôle Est :
Pr PEYRIN-BIROULET Laurent

Tous les auteurs :
Guinet-Charpentier C, Bilbault C, Kennel A, Perrier P, Peyrin-Biroulet L, Morali A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25440769

Résumé

Ulcerative colitis (UC) is a chronic inflammatory condition. Its incidence is 0.8 per 100,000 children per year and median age at diagnosis is 14.1 years in the pediatric population. Extradigestive manifestations are frequent in inflammatory bowel disease (IBD), but neurologic disorders are rarely associated. We report the case of a 14-year-old boy who was diagnosed with UC and thereafter autoimmune hepatitis with primary sclerosing cholangitis. Two months later, he also developed myasthenia gravis, another autoimmune disease. Physicians should be aware of the possibility of an association between several autoimmune diseases in patients with IBD in order to improve disease outcomes.

Mots clés

Adolescent, Cholangitis, Sclerosing, complications, Colitis, Ulcerative, complications, Hepatitis, Autoimmune, complications, Humans, Male, Myasthenia Gravis, complications

Référence

Arch Pediatr. 2015 Jan;22(1):81-3