Fiche publication
Date publication
décembre 2019
Journal
Essays in biochemistry
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BARDET Anaïs
Tous les auteurs :
Héberlé É, Bardet AF
Lien Pubmed
Résumé
Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional states throughout organism development. Epigenetics modifications, such as DNA methylation mostly within cytosine-guanine dinucleotides (CpGs), have the potential to modulate TF binding to DNA. Although DNA methylation has long been thought to repress TF binding, a more recent model proposes that TF binding can also inhibit DNA methylation. Here, we review the possible scenarios by which DNA methylation and TF binding affect each other. Further in vivo experiments will be required to generalize these models.
Mots clés
DNA methylation, Transcription factor, gene regulation
Référence
Essays Biochem. 2019 12 20;63(6):727-741
