Titanate nanoribbon-based nanobiohybrid for potential applications in regenerative medicine.

Date publication

septembre 2022

Journal

RSC advances

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MILLOT Nadine , Pr DENAT Franck , Dr BOUDON Julien

Tous les auteurs :
Maurizi L, Bellat V, Moreau M, De Maistre E, Boudon J, Dumont L, Denat F, Vandroux D, Millot N

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/36320832

Résumé

Nanoparticles capable of mimicking natural tissues represent a major technological advancement in regenerative medicine. In this pilot study, the development of a new nanohybrid composed of titanate nanoribbons to mimic the extracellular matrix is reported. During the first phase, nanoribbons were synthesized by hydrothermal treatment. Subsequently, titanate nanoribbons were functionalized by heterobifunctional polyethylene-glycol (PEG) to graft type I collagen on their surface. Biological properties of this new nanobiohybrid such as cytotoxicity to cardiac cells and platelet aggregation ability were evaluated. The so-formed nanobiohybrid permits cellular adhesion and proliferation favoring fine cardiac tissue healing and regeneration.

Référence

RSC Adv. 2022 09 16;12(41):26875-26881