[Mecanisms of pharmacokinetic interactions involving oral anticancer agents].

Date publication

janvier 2015

Journal

Bulletin du cancer

Auteurs

Membres identifiés du Cancéropôle Est :
Dr DORY Anne

Tous les auteurs :
Levêque D, Duval C, Poulat C, Palas B, El Aatmani A, Dory A, Becker G, Gourieux B

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25609481

Résumé

Oral anticancer agents and particularly kinase inhibitors are subject to pharmacokinetic drug interactions in relation to absorption and elimination phases. Interacting factors are food, fruit juices, cigarette smoke, acid-reducing agents and inducers/inhibitors. Some anticancer agents are inducers and/or inhibitors and can also perpetrate drug interactions. This review emphasizes the mechanisms of pharmacokinetic drug interactions involving oral anticancer agents.

Mots clés

Agents anticancéreux oraux, Drug interaction, Interaction médicamenteuses, Oral anticancer agents, Pharmacocinétique, Pharmacokinetics

Référence

Bull Cancer. 2015 01;102(1):65-72