Dynamized ultra-low dilution of disrupts plasma membrane organization and decreases migration of melanoma cancer cell.

Fiche publication

Date publication

décembre 2023

Journal

Cell adhesion & migration

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MARTINY Laurent , Dr TERRYN Christine , Dr SCHNEIDER Christophe , Dr BERQUAND Alexandre

Tous les auteurs :
Fuselier C, Dufay E, Berquand A, Terryn C, Bonnomet A, Molinari M, Martiny L, Schneider C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/36503402

Résumé

Cutaneous melanoma is a cancer with a very poor prognosis mainly because of metastatic dissemination and therefore a deregulation of cell migration. Current therapies can benefit from complementary medicines as supportive care in oncology. In our study, we show that a dynamized ultra-low dilution of leads to an inhibition of migration on fibronectin of B16F10 melanoma cells, as well as a decrease in metastatic dissemination . These effects appear to be due to a disruption of plasma membrane organization, with a change in cell and membrane stiffness, associated with a disorganization of the actin cytoskeleton and a modification of the lipid composition of the plasma membrane. Together, these results demonstrate, in and models of cutaneous melanoma, an anti-cancer and anti-metastatic activity of ultra-low dynamized dilution of and reinforce its interest as complementary medicine in oncology.