Acute toxicities and cumulative dose to the brain of repeated sessions of stereotactic radiotherapy (SRT) for brain metastases: a retrospective study of 184 patients.

Date publication

janvier 2023

Journal

Radiation oncology (London, England)

Auteurs

Membres identifiés du Cancéropôle Est :
Pr ANTONI Delphine , Pr NOEL Georges , Dr CEBULA Hélène , Dr LE FEVRE Clara

Tous les auteurs :
Kuntz L, Le Fèvre C, Jarnet D, Keller A, Meyer P, Thiery A, Cebula H, Noel G, Antoni D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/36627646

Résumé

Stereotactic radiation therapy (SRT) is a focal treatment for brain metastases (BMs); thus, 20 to 40% of patients will require salvage treatment after an initial SRT session, either because of local or distant failure. SRT is not exempt from acute toxicity, and the acute toxicities of repeated SRT are not well known. The objective of this study was to analyze the acute toxicities of repeated courses of SRT and to determine whether repeated SRT could lead to cumulative brain doses equivalent to those of whole-brain radiotherapy (WBRT).

Mots clés

Acute toxicity, Brain metastases, Repeated radiosurgery, Salvage radiation, Side effect, Stereotactic radiosurgery

Référence

Radiat Oncol. 2023 01 10;18(1):7