Fiche publication
Date publication
janvier 2023
Journal
Methods in molecular biology (Clifton, N.J.)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DAUCHEZ Manuel
,
Pr BAUD Stéphanie
Tous les auteurs :
Rao RM, Belloy N, Crowet JM, Dauchez M, Baud S
Lien Pubmed
Résumé
While the knowledge of protein structure and function has seen vast advances in previous decades, the understanding of how their posttranslational modifications, such as glycosylations, influence their structure and function remains poor. However, advances in in silico methodologies to study glycosylations in recent past have enabled us to study this and understand the role of glycosylations in protein structure and function in ways that would not be possible by conventional experimental methods. In this chapter, we will demonstrate how to leverage these methodologies to study glycoproteins and their structural and dynamic properties using molecular modelling techniques.
Mots clés
Glycoproteins, Glycosylation, Molecular dynamics, Molecular modelling, Posttranslational modifications, Web portal CHARMM-GUI, doGlycans
Référence
Methods Mol Biol. 2023 ;2619:293-313
