PAX-FOXO1 fusion status in children and adolescents with alveolar rhabdomyosarcoma: Impact on clinical, pathological, and survival features.

Fiche publication

Date publication

janvier 2023

Journal

Pediatric blood & cancer

Auteurs

Membres identifiés du Cancéropôle Est :
Dr DESANDES Emmanuel , Dr LACOUR Brigitte

Tous les auteurs :
Raze T, Lapouble E, Lacour B, Guissou S, Defachelles AS, Gaspar N, Delattre O, Pierron G, Desandes E

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/36722003

Résumé

Alveolar rhabdomyosarcoma (ARMS) is an aggressive pediatric cancer and cases with fusion PAX3-FOXO1 and PAX7-FOXO1 seem to have a poor prognosis. The aim is to evaluate whether PAX-FOXO1 alterations influence clinical outcome in childhood and adolescence population with ARMS.