Do proton pump inhibitors alter the response to immune checkpoint inhibitors in cancer patients? A meta-analysis.

Fiche publication

Date publication

janvier 2023

Journal

Frontiers in immunology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MASCAUX Céline , Dr DORY Anne

Tous les auteurs :
Lopes S, Pabst L, Dory A, Klotz M, Gourieux B, Michel B, Mascaux C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/36776847

Résumé

Gut microbiota can significantly affect the effectiveness of immune checkpoint inhibitors (ICIs) in cancer patients. Recently, antibiotics were shown to decrease survival rate of patients treated by ICIs. Proton pump inhibitors (PPIs) can indeed modulate microbiota's diversity, therefore altering ICIs response. A meta-analysis was performed based on published data to verify this hypothesis.