Gut virome-colonising genus is associated with ulcerative colitis pathogenesis and induces intestinal inflammation .

Date publication

février 2023

Journal

Gut

Auteurs

Membres identifiés du Cancéropôle Est :
Pr PEYRIN-BIROULET Laurent

Tous les auteurs :
Massimino L, Palmieri O, Facoetti A, Fuggetta D, Spanò S, Lamparelli LA, D'Alessio S, Cagliani S, Furfaro F, D'Amico F, Zilli A, Fiorino G, Parigi TL, Noviello D, Latiano A, Bossa F, Latiano T, Pirola A, Mologni L, Piazza RG, Abbati D, Perri F, Bonini C, Peyrin-Biroulet L, Malesci A, Jairath V, Danese S, Ungaro F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/36788014

Résumé

Ulcerative colitis (UC) is a chronic inflammatory disorder of unknown aetiology. Gut virome dysbiosis is fundamental in UC progression, although its role in the early phases of the disease is far from fully understood. Therefore, we sought to investigate the role of a virome-associated protein encoded by the genus, the hepatitis B virus X protein (HBx), in UC aetiopathogenesis.

Mots clés

chronic ulcerative colitis, experimental colitis, inflammation, intestinal microbiology, mucosal immunity

Référence

Gut. 2023 02 14;: