Biomimetic Bilayered Scaffolds For Tissue Engineering: From Current Design Strategies To Medical Applications.

Fiche publication

Date publication

février 2023

Journal

Advanced healthcare materials

Auteurs

Membres identifiés du Cancéropôle Est :
Dr LAVALLE Philippe , Pr DEBRY Christian

Tous les auteurs :
Bertsch C, Maréchal H, Gribova V, Lévy B, Debry C, Lavalle P, Fath L

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/36807830

Résumé

Tissue damage due to cancer, congenital anomalies, and injuries need new efficient treatments that allow tissue regeneration. In this context, tissue engineering shows a great potential to restore the native architecture and function of damaged tissues, by combining cells with specific scaffolds. Scaffolds made of natural and/or synthetic polymers and sometimes ceramics play a key role in guiding cell growth and formation of the new tissues. Monolayered scaffolds, which consist of uniform material structure, were reported as not being sufficient to mimic complex biological environment of the tissues. Osteochondral, cutaneous, vascular and many other tissues all have multilayered structure, therefore multilayered scaffolds seem more advantageous to regenerate these tissues. In this review, we focus on recent advances in bilayered scaffolds design applied to regeneration of vascular, bone, cartilage, skin, periodontal, urinary bladder, and tracheal tissues. After short introduction on tissue anatomy, composition, and fabrication techniques of bilayered scaffolds are explained. Then, experimental results obtained in vitro and in vivo are described, and their limitations are given. Finally, we discuss difficulties in scaling up production of bilayer scaffolds and reaching the stage of clinical studies when multiple scaffold components are used. This article is protected by copyright. All rights reserved.