Fiche publication
Date publication
décembre 2020
Journal
Medecine sciences : M/S
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BENSUSSAN Armand
Tous les auteurs :
Boismal F, Serror K, Dobos G, Zuelgaray E, Bensussan A, Michel L
Lien Pubmed
Résumé
One of the major challenges of the 21 century is the fight against aging, defined as a set of physiological mechanisms altering the physical and intellectual capacities of human beings. Aging of the skin is only one visible part of this process. It is associated with major healing defects linked in part to the alteration of the biomechanical properties of skin cells, mainly dermal fibroblasts. The immune system, another key component in maintaining skin homeostasis and the efficient healing of wounds, also suffers the effects of time: the consequent skin immunosenescence would limit the anti-infectious and vaccine response, while promoting a pro-tumor environment. The main skin damages due to aging, whether intrinsic or extrinsic, will be detailed before listing the effective anti-aging strategies to combat age-related dermal and epidermal stigmas.
Mots clés
Aging, drug effects, Animals, Cellular Senescence, drug effects, Drugs, Investigational, pharmacology, Epidermis, drug effects, Humans, Skin, blood supply, Skin Aging, drug effects, Therapies, Investigational, methods, Wound Healing, physiology
Référence
Med Sci (Paris). 2020 12;36(12):1163-1172
