High-frequency oscillations and spikes running down after SEEG-guided thermocoagulations in the epileptogenic network of periventricular nodular heterotopia.

Fiche publication

Date publication

février 2019

Journal

Epilepsy research

Auteurs

Membres identifiés du Cancéropôle Est :
Pr PROUST François

Tous les auteurs :
Scholly J, Pizzo F, Timofeev A, Valenti-Hirsch MP, Ollivier I, Proust F, Roehri N, Bénar CG, Hirsch E, Bartolomei F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/30610969

Résumé

Epilepsy associated with periventricular nodular heterotopia (PNH) is characterized by complex relationships between the heterotopic and the normotopic cortex during the interictal state and at seizure onset. High-frequency oscillations (HFO) have been proposed as a marker of epileptogenicity that might reflect disease activity. The effects of thermocoagulations on epileptogenicity in this context remain unknown. We aimed to investigate the interictal HFO- and spike profiles of different cortical structures before and after two consecutive SEEG-guided thermocoagulations, in correlation with seizure outcome, in a patient with PNH-related drug-resistant epilepsy.