Gut microbiota remodeling and intestinal adaptation to lipid malabsorption after enteroendocrine cell loss in adult mice.

Fiche publication

Date publication

février 2023

Journal

Cellular and molecular gastroenterology and hepatology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr DE ARCANGELIS Adèle , Dr GRADWOHL Gérard

Tous les auteurs :
Blot F, Marchix J, Ejarque M, Jimenez S, Meunier A, Keime C, Trottier C, Croyal M, Lapp C, Mahe MM, De Arcangelis A, Gradwohl G

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/36858136

Résumé

Enteroendocrine cells (EECs) and their hormones are essential regulators of whole-body energy homeostasis. EECs sense luminal nutrients and microbial metabolites and subsequently secrete various hormones acting locally or at a distance. Impaired development of EECs during embryogenesis is life-threatening in newborn mice and humans due to compromised nutrient absorption. However, the physiological importance of the EEC system in adult mice has yet to be directedly studied. Herein, we aimed to determine the long-term consequences of a total loss of EECs in healthy adults on energy metabolism, intestinal transcriptome and microbiota.