A new cure model that corrects for increased risk of non-cancer death: analysis of reliability and robustness, and application to real-life data.

Date publication

mars 2023

Journal

BMC medical research methodology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr JOOSTE Valérie

Tous les auteurs :
Botta L, Goungounga J, Capocaccia R, Romain G, Colonna M, Gatta G, Boussari O, Jooste V

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/36966273

Résumé

Non-cancer mortality in cancer patients may be higher than overall mortality in the general population due to a combination of factors, such as long-term adverse effects of treatments, and genetic, environmental or lifestyle-related factors. If so, conventional indicators may underestimate net survival and cure fraction. Our aim was to propose and evaluate a mixture cure survival model that takes into account the increased risk of non-cancer death for cancer patients.

Mots clés

Cancer, Cure model, Increased non-cancer mortality, Life tables, Net survival, Population-based data, Reliability, Robustness

Référence

BMC Med Res Methodol. 2023 03 25;23(1):70