Pholcodine exposure increases the risk of perioperative anaphylaxis to neuromuscular blocking agents: the ALPHO case-control study.

Fiche publication

Date publication

mars 2023

Journal

British journal of anaesthesia

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GILLET Pierre , Pr GUEANT Jean-Louis

Tous les auteurs :
Mertes PM, Petitpain N, Tacquard C, Delpuech M, Baumann C, Malinovsky JM, Longrois D, Gouel-Cheron A, Le Quang D, Demoly P, Guéant JL, Gillet P,

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/36967281

Résumé

Neuromuscular blocking agents (NMBAs) are among the leading cause of perioperative anaphylaxis, and most of these reactions are IgE mediated. Allergic sensitisation induced by environmental exposure to other quaternary ammonium-containing compounds, such as pholcodine, has been suggested. The aim of this study was to assess the relationship between pholcodine exposure and NMBA-related anaphylaxis.