The Mechanism of Action of SAAP-148 Antimicrobial Peptide as Studied with NMR and Molecular Dynamics Simulations.

Date publication

février 2023

Journal

Pharmaceutics

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BECHINGER Burkhard

Tous les auteurs :
Adélaïde M, Salnikov E, Ramos-Martín F, Aisenbrey C, Sarazin C, Bechinger B, D'Amelio N

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/36986623

Résumé

SAAP-148 is an antimicrobial peptide derived from LL-37. It exhibits excellent activity against drug-resistant bacteria and biofilms while resisting degradation in physiological conditions. Despite its optimal pharmacological properties, its mechanism of action at the molecular level has not been explored.

Mots clés

NMR, antimicrobial, biomembranes, membrane topology, molecular dynamics, paramagnetic relaxation enhancement, peptides, solid-state NMR spectroscopy

Référence

Pharmaceutics. 2023 02 24;15(3):