In vivo validation of Ga-labeled AMD3100 conjugates for PET imaging of CXCR4.

Fiche publication

Date publication

avril 2023

Journal

Nuclear medicine and biology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr DENAT Franck

Tous les auteurs :
Renard I, Domarkas J, Poty S, Burke BP, Roberts DP, Goze C, Denat F, Cawthorne CJ, Archibald SJ

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/37068392

Résumé

The chemokine receptor CXCR4 has been shown to be over-expressed in multiple types of cancer and is usually associated with aggressive phenotypes and poor prognosis. Successfully targeting and imaging the expression level of this receptor in tumours could inform treatment selection and facilitate patient stratification.