Fiche publication
Date publication
mars 2023
Journal
Biological psychiatry
Auteurs
Membres identifiés du Cancéropôle Est :
Dr HERAULT Yann
Tous les auteurs :
Guedj F, Kane E, Bishop LA, Pennings JLA, Herault Y, Bianchi DW
Lien Pubmed
Résumé
Despite successful preclinical treatment studies to improve neurocognition in the Ts65Dn mouse model of Down syndrome, translation to humans has failed. This raises questions about the appropriateness of the Ts65Dn mouse as the gold standard. We used the novel Ts66Yah mouse that carries an extra chromosome and the identical segmental Mmu16 trisomy as Ts65Dn without the Mmu17 non-Hsa21 orthologous region.
Mots clés
Down syndrome, Mmu17 non-Hsa21 orthologous genes, Mouse models, Phenotype, Trisomy 21, Ts65Dn, Ts66Yah
Référence
Biol Psychiatry. 2023 03 14;:
