UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis.

Date publication

décembre 2014

Journal

Arthritis research & therapy

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MAGDALOU Jacques

Tous les auteurs :
Wen Y, Li J, Wang L, Tie K, Magdalou J, Chen L, Wang H

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25465897

Résumé

The objective of this study was to investigate the possible role of UDP-glucose dehydrogenase (UGDH) in osteoarthritis (OA) and uncover whether, furthermore how interleukin-1beta (IL-1β) affects UGDH gene expression.

Mots clés

Aged, Animals, Cartilage, Articular, metabolism, Cells, Cultured, Chondrocytes, metabolism, Female, Humans, Middle Aged, Osteoarthritis, metabolism, Proteoglycans, antagonists & inhibitors, RNA, Small Interfering, pharmacology, Rats, Rats, Wistar, Uridine Diphosphate Glucose Dehydrogenase, antagonists & inhibitors

Référence

Arthritis Res. Ther.. 2014 Dec 3;16(6):484