Effect of an intraoperative periradicular application of platelet-rich fibrin (PRF) on residual post-surgical neuropathic pain after disc herniation surgery: study protocol for NeuroPRF, a randomized controlled trial.

Date publication

juin 2023

Journal

Trials

Auteurs

Membres identifiés du Cancéropôle Est :
Dr VALLAT Laurent , Pr POISBEAU Pierrick , Pr PROUST François

Tous les auteurs :
Todeschi J, Dannhoff G, Coca AH, Timbolschi DI, Proust F, Lefebvre F, Lelievre V, Poisbeau P, Vallat L, Salvat E, Bohren Y

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/37337269

Résumé

The prevalence of post-surgical lumbar neuropathic radiculopathy is approximately 30%. Poor response to the recommended treatments for neuropathic pain, namely antidepressants and/or gabapentinoids, requires the development of new techniques to prevent chronic pain. One such well-tolerated technique is the administration of autologous plasma enriched in platelets and fibrin (PRF). This approach is largely used in regenerative medicine owing to the anti-inflammatory and analgesic properties of PRF. It could also be an interesting adjuvant to surgery, as it reduces neurogenic inflammation and promotes nerve recovery, thereby reducing the incidence of residual postoperative chronic pain. The aim of the present study is to evaluate the benefit of periradicular intraoperative application of PRF on the residual postsurgical neuropathic pain after disc herniation surgery.

Mots clés

Humans, Intervertebral Disc Displacement, diagnosis, Chronic Pain, drug therapy, Platelet-Rich Fibrin, Quality of Life, Prospective Studies, Single-Blind Method, Analgesics, therapeutic use, Neuralgia, diagnosis, Pain, Postoperative, diagnosis, Treatment Outcome, Randomized Controlled Trials as Topic

Référence

Trials. 2023 06 19;24(1):418