The presence of senescent peripheral T-cells is negatively correlated to COVID-19 vaccine-induced immunity in cancer patients under 70 years of age.

Date publication

juin 2023

Journal

Frontiers in immunology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BORG Christophe , Mme BOUARD Adeline , Dr MANSI Laura , Dr VIENOT Angélique , Dr KROEMER Marie , Mr FALCOZ Antoine

Tous les auteurs :
Orillard E, Spehner L, Mansi L, Bouard A, Falcoz A, Lepiller Q, Renaude E, Pallandre JR, Vienot A, Kroemer M, Borg C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/37334387

Résumé

Cancer patients are at risk of severe COVID-19 infection, and vaccination is recommended. Nevertheless, we observe a failure of COVID-19 vaccines in this vulnerable population. We hypothesize that senescent peripheral T-cells alter COVID-19 vaccine-induced immunity.

Mots clés

COVID-19, vaccination, T lymphocyte (T-cell), cancer patient, predictive biomarker, senescence

Référence

Front Immunol. 2023 06 2;14:1160664