Long Terms Follow-Up of the Randomized MetaspHER Study Comparing Intravenous Versus Subcutaneous Trastuzumab in Patients' With HER2-Positive Metastatic Breast Cancer.

Fiche publication

Date publication

juin 2023

Journal

Clinical breast cancer

Auteurs

Membres identifiés du Cancéropôle Est :
Pr PIVOT Xavier , Dr SPAETH Dominique , Dr JOUANNAUD Christelle

Tous les auteurs :
Pivot X, Spano JP, Espie M, Jouannaud C, Pottier V, Moreau L, Extra JM, Lortholary A, Rivera P, Spaeth D, Mouri Z, Tariket F, Dupin J, Berthois A, Ionescu-Goga M, Ferhat A, Cottu P, Gligorov J

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/37423801

Résumé

The subcutaneous (H-SC) formulation of trastuzumab was demonstrated to be as effective and safe as intravenous (H-IV) and highly preferred by patients in early breast cancer. The present randomized MetaspHER trial (NCT01810393) has been the first study assessing patient's preference in metastatic setting and we report the final analysis with long term follow-up.