Fiche publication


Date publication

juin 2023

Journal

Molecules (Basel, Switzerland)

Auteurs

Membres identifiés du Cancéropôle Est :
Dr BRASSART-PASCO Sylvie , Dr MONBOISSE Jean-Claude


Tous les auteurs :
Kordkatooli E, Bacha K, Villaume S, Dorey S, Monboisse JC, Brassart-Pasco S, Mbakidi JP, Bouquillon S

Résumé

Symmetrical and dissymmetrical bolaforms were prepared with good to high yields from unsaturated L-rhamnosides and phenolic esters (ferulic, phloretic, coumaric, sinapic and caffeic) using two eco-compatible synthetic strategies involving glycosylation, enzymatic synthesis and cross-metathesis under microwave activation. The plant-eliciting activity of these new compounds was investigated in Arabidopsis model plants. We found that the monocatenar rhamnosides and bolaforms activate the plant immune system with a response depending on the carbon chain length and the nature of the hydrophilic heads. Their respective antioxidant activities were also evaluated, as well as their cytotoxic properties on dermal cells for cosmetic uses. We showed that phenolic ester-based compounds present good antioxidant activities and that their cytotoxicity is low. These properties are also dependent on the carbon chains used.

Mots clés

amphiphilic, antioxidant, bolaform, dermal cytotoxicity, microwaves, monocatenar, phenolic acids, plant immunity, rhamnosides

Référence

Molecules. 2023 06 30;28(13):