Fiche publication
Date publication
août 2023
Journal
Steroids
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DUBOIS-POT-SCHNEIDER Hélène
,
Dr DUMOND Hélène
,
Dr RECH Fabien
Tous les auteurs :
Hirtz A, Rech F, Dubois-Pot-Schneider H, Dumond H
Lien Pubmed
Résumé
Sex-specific differences in brain organization and function are widely explored in multidisciplinary studies, ranging from sociology and biology to digital modelling. In addition, there is growing evidence that natural or disturbed hormonal environments play a crucial role in the onset of brain disorders and pathogenesis. For example, steroid hormones, but also enzymes involved in steroidogenesis and receptors triggering hormone signaling are key players of gliomagenesis. In the present review we summarize the current knowledge about steroid hormone, particularly estrogens synthesis and signaling, in normal brain compared to the tumor brain. We will focus on two key molecular players, aromatase and the G Protein-Coupled Estrogen Receptor, GPER.
Mots clés
Aromatase, Brain, GPER, Glioma, Steroid hormones
Référence
Steroids. 2023 08 3;:109285
