Fiche publication
Date publication
juillet 2023
Journal
Biological psychiatry
Auteurs
Membres identifiés du Cancéropôle Est :
Dr NOBLET Vincent
,
Dr DARCQ Emmanuel
Tous les auteurs :
Sourty M, Nasseef MT, Champagnol-Di Liberti C, Mondino M, Noblet V, Parise EM, Markovic T, Browne CJ, Darcq E, Nestler EJ, Kieffer BL
Lien Pubmed
Résumé
The transcription factor, ΔFOSB, acting in the nucleus accumbens (NAc), has been shown to control transcriptional and behavioral responses to opioids and other drugs of abuse. However, circuit-level consequences of ΔFOSB induction on the rest of the brain-required for its regulation of complex behavior-remain unknown.
Mots clés
Fosb gene expression, bi-directional epigenetic manipulation, brain connectivity, habenula, mouse fMRI, prefrontal cortex
Référence
Biol Psychiatry. 2023 07 28;:
