A new triterpene saponin and known compounds from the polar extract of L. and evaluation of their antioxidant activity.

Fiche publication

Date publication

septembre 2023

Journal

Natural product research

Auteurs

Membres identifiés du Cancéropôle Est :
Dr ALABDULMAGID Abdulmagid

Tous les auteurs :
Lakhal H, Kabouche A, Kabouche Z, Bechkri S, AlabdulMagid A, Voutquenne-Nazabadioko L, Harakat D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/37747774

Résumé

A new triterpene saponin, 2, 3, 21, 23-tetrahydroxyolean-12-en-28-oic-acid-28--β-D- glucosyl-(2''→1')-β-D-glucoside (), was isolated from the -butanol extract of dried aerial parts of L. (Lamiaceae) in addition to two known flavonoids, apigenin 7--β-D-glucoside (), threo-guaiacylglycerol 3--[6---hydroxybenzoyl]-β-D-glucoside (), luteolin 7--β-D-glucoside (), verbascoside () and rosmarinic acid (). The structure elucidation of these compounds was based on analyses of spectroscopic data including 1D-, 2D-NMR and HR-ESI-MS techniques and by comparing their NMR data with those reported in the literature. Compound exhibited the highest antioxidant activity in DPPH assay (IC<3.00 µg/mL) which was better than the standards BHA, BHT, Trolox and ascorbic acid.